Newdirran ® probiotics are manufactured in Italiy by Probiotical S.p.A. Founded in 1985 in Novara, Italy, Probiotical has more than 30 years experience and is among the top five probiotics manufacturers in the world. Probiotical has full competence and qualifications for producing active pharmaceutical ingredients and has cutting edge R&D setup, including 1,200 square meters of clean laboratories designated to probiotics research and production. Presently, it owns more than 80 patents related to probiotic products.